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（腫瘤轉化醫學中心）

個人簡介

李紀良 (JILIANG LI, MMed, PhD)，系英國倫敦大學博士、牛津大學博士后、Imperial Cancer Research Fund (ICRF) Fellow、Cancer Research UK (CRUK)/牛津大學終身科學家、英國著名大學醫學院腫瘤學終身教授/主任、浙江省特聘專家、中國科學院大學溫州研究院兼職教授、腫瘤轉化醫學中心負責人。承擔、參與和完成多項重大腫瘤科技項目，多次受邀在國際學術會議上作大會報告，并在Cancer Cell、Cell Metabolism、Hepatology、Blood、Nature Commun、PNAS和Cancer Research為代表的多種國際專業主流期刊上發表SCI論文90多篇。其論文被包括Nature、Science和Cell等在內的著名專業雜志引用9000多次 (按Google Scholar檢索)，期中最高單篇論文被引>940多次，單篇論文被引>100次的有28篇，H-因子48。擔任American Journal of Cancer Research等10余家國際學術雜志編委。擔任英國、德國、法國、荷蘭、新西蘭、新加坡等眾多國家基金項目特邀評審專家及Nature Commun、Hepatology、Gut、Blood、PNAS、Cancer Research、Clinical Cancer Research和Journal of Pathology等40多家國際專業性雜志評審專家。在腫瘤學相關領域內享有較高的學術聲譽，兩次受Cancer Cell 雜志社特邀對發表于該刊當期最新論文撰寫述評，并受雜志社特邀對最新Nature論文撰寫述評。

研究領域

Our research interest focuses on tumour microenvironment and translational cancer medicine. By employing a variety of approaches including molecular and cellular biology, immunology, proteomics, single cell sequencing, bioinformatics, animal pre-clinical models, and human tumour samples, our research is dedicated to delineate mechanisms on how key molecules (such as microRNAs, lncRNAs, and RNF181 E3 ligase), signalling pathways (such as Notch signalling), tumour cells, and tumour stromal cells (such as endothelial cells, infiltrated lymphocytes, tumour-associated macrophages, and tumour-associated fibroblasts) in tumour microenvironment regulate tumour growth, invasion and metastasis, and tumour response to standard therapeutic interventions (in particular, cross-interactions among radiotherapy, chemotherapy, targeted therapy or immunotherapy). Our aims are (1) to dissect mechanisms of tumour invasion and metastasis; (2) to develop novel therapeutic targets; (3) to improve therapeutic efficacy by optimal combinations of radiotherapy, chemotherapy, targeted therapy, or immunotherapy; and (4) to develop novel biomarkers for the prediction of therapeutic efficacy and/or patient prognosis. Primary cancer types we are currently working on include, but not limit to, ocular cancer (eg, uveal melanoma and retinoblastoma), brain tumour (eg, glioblastoma), gastrointestinal tumour (eg, gastric, colorectal and hepatic cancer), and head & neck cancer (eg, nasopharyngeal carcinoma). We are extremely keen to work together with people who have a great passions on pursuing a splendid scientific career in molecular, stratified and translational oncology. Enquiries with CV welcome to contact for details (Email: jlilab1971@163.com).

代表論文

1. Li JL and Harris AL.: The potential of new tumor endothelium-specific markers for the development of anti-vascular therapy. Cancer Cell, 2007;11(6):478-482 (通信作者). (5 year IF = 26.809).

2. Li JL and Harris AL.: Notch signaling from tumor cells: a new mechanism of angiogenesis. Cancer Cell, 2006; 8(1): 1-4 (通信作者) (5 year IF = 26.809).

3. Masiero  M, Sim?es FC, Han HD, Snell C, Peterkin T, Bridges E, Li D, Han C, Tuynman JB, Mortensen N,  Li JL, et al.: A core human primary tumor angiogenesis signature identifies ELTD1, an endothelial orphan receptor regulating angiogenesis. Cancer Cell, 2013; 24(2): 229-241 (5 year IF = 26.809).

4. Favaro E, Bensaad K, Chong M, Tennant D, Ferguson D, Snell C, Steers G, Turley H, Li JL, et al.: Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells. Cell Metabolism, 2012; 16(6): 751-764 (5 year IF = 22.787).

5. Wang S, Huang X, Li Y, Lao H, Zhang Y, Dong H, Xu W, Li JL and Li M.: RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway. Hepatology, 2012; 53(6): 1932-1942 (通信作者) (IF = 14.971).

6. Cai L, Ye Y, Jiang Q, Lyu XM, Chen Y, Li JB, Wang S, Liu T, Yao KT, Li JL and Li X.:  Epstein-Barr Virus-encoded microRNA BART1 impels tumor metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma. Nature Commun, 2015; 6: 7353 (通信作者) (5 year IF = 13.811).

7. Li JL, Sanson RC, Oon CE, Turley H, Leek R, Sheldon H, Bridge, E, Shi W, Snell C, Bowden ET, Wu H, Chowdhury PS, Russell AJ, Montgomery CP, Poulsom R and Harris AL.: DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. Cancer Research, 2011; 71(18):6073-6083 (通信作者) (5 year IF = 9.062).

8. Li JL, Sainson RC, Shi W, Leek R, Harrington LS, Preusser M, Biswas S, Turley H, Heikamp E, Hainfellner JA and Harris AL.: Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function and promotes tumor growth in vivo. Cancer Research, 2007; 67(23): 11244-11253 (通信作者) (5 year IF = 9.062).

9. Patel NS, Li JL, Generali D, Poulsom R, Cranston DW and Harris AL.: Upregulation of delta-like 4 ligand in human tumour vasculature and the role of basal expression in endothelial cell function. Cancer Research, 2006; 65(19): 8690-8697 (通信作者) (5 year IF = 9.062).

10. Wang S, Wang X, Gao Y, Peng Y, Dong N, Zhang X, Wu Y, Li M and Li JL.:  RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK-cyclin D1/CDK4 pathway. The Journal of Pathology, 2019; 248(2): 204-216 (通信作者) (5 year IF = 6.424).